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Table 1 summarizes the observed DLTs by cohort. Somnolence, which solved in all but a single affected person, was the one DLT for MLN8054 presented devoid of methylphenidate or modafinil. The onset of somnolence and its severity typically were being correlated with dose and Cmax. Because somnolence was thought to be connected with Cmax, the dosing

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